Ursodeoxycholic Acid and Pregnancy: What You Need to Know

If you’ve been told you have intrahepatic cholestasis of pregnancy (ICP) or another liver issue, chances are your doctor mentioned ursodeoxycholic acid (UDCA). This medication helps lower bile acids that build up and cause itching, premature labor, or fetal distress. Below we’ll break down why it’s used, how to take it safely, and what to watch for.

Why UDCA Is Commonly Prescribed During Pregnancy

UDCA is a naturally occurring bile acid that replaces the toxic ones stuck in your liver. By doing that, it eases the itching and reduces the risk of the baby being exposed to high bile‑acid levels. Studies show that women who take the right dose of UDCA have lower rates of pre‑term birth and better birth outcomes compared with untreated ICP.

How to Take UDCA Safely

The usual dose for pregnant women is 13‑15 mg per kilogram of body weight, split into two or three doses each day. Most doctors start with 500 mg tablets taken twice daily and adjust based on lab results. Take the pills with food to limit stomach upset, and keep a weekly blood test schedule so your doctor can track bile‑acid levels.

Don’t skip doses, and let your provider know right away if you notice new symptoms like severe nausea, vomiting, or a rash. These could be signs of a rare reaction. Drinking plenty of water and eating a balanced diet with fiber can also help your liver process the medication more effectively.

Most pregnant women tolerate UDCA well. The most common side effects are mild stomach discomfort and occasional diarrhea. If you’re on other medications, ask your doctor about possible interactions—especially with other bile‑acid pills or certain antibiotics.

While UDCA is considered safe, it’s still a prescription drug, so you’ll need a valid prescription from a qualified healthcare professional. Avoid buying it from unverified online sources; counterfeit pills can be dangerous for both you and your baby.

If you’re planning a pregnancy and have a history of liver problems, discuss UDCA with your OB‑GYN before trying to conceive. Starting treatment early, if needed, can make the pregnancy smoother and reduce the chance of complications later on.

Remember that UDCA does not replace regular prenatal care. Keep all your prenatal appointments, monitor your baby's movements, and report any new itching or abdominal pain to your doctor immediately.

In summary, ursodeoxycholic acid is a proven tool for managing cholestasis and protecting fetal health. Follow your doctor’s dosing instructions, stay on top of lab tests, and maintain a healthy lifestyle to get the best results.